People Who Have Had COVID Face a Much Higher Risk of Chronic Fatigue
A new CDC study shows the virus can lead to unrelenting exhaustion—here’s why.
What Repeat COVID Infections Do to Your Body, According to Science
This virus behaves differently in our bodies than cold and flu—and can do major long-term damage.
What Repeat COVID Infections Do to Your Body, According to Science
Yes, It’s Still Really Worth Avoiding COVID—Even If You’ve Already Had It a Few Times.
We can, and must, do more to protect students in higher education from the risks of post-COVID condition
Postsecondary students are particularly vulnerable to repeated COVID-19 infections, putting them at risk for post-COVID condition, or long COVID. Campuses can take action to protect them.
Canada needs a national COVID-19 inquiry now - BMC Medicine
"In addition to the acute impacts of deaths and hospitalizations, there is growing awareness of an accumulation of organ damage and disability which is building a “health debt” that will affect Canadians for decades to come. Calls in 2023 for an inquiry into the handling of the COVID-19 pandemic went unheeded, despite relevant precedent. Canada urgently needs a comprehensive review of its successes and failures to chart a better response in the near- and long-term."
COVID-19 related cognitive, structural and functional brain changes among Italian adolescents and young adults: a multimodal longitudinal case-control study
“One out of four mild COVID-19 subjects reported persistent deficits in higher cognitive functions like concentration, memory, visuospatial and visuoconstructive abilities.”
Spike Protein Lingers in Brain, Fuels Long COVID - Neuroscience News
A new study reveals that the SARS-CoV-2 spike protein remains in brain-protective tissues and skull bone marrow for years after infection, potentially driving long COVID’s neurological symptoms.
Even mild cases of COVID-19 can leave a mark on the brain, such as reductions in gray matter – a neuroscientist explains emerging research
"The team found marked differences in gray matter – or the neurons that process information in the brain – between those who had been infected with COVID-19 and those who had not. Specifically, the thickness of the gray matter tissue in brain regions known as the frontal and temporal lobes was reduced in the COVID-19 group, differing from the typical patterns seen in the people who hadn’t had a COVID-19 infection.
In the general population, it is normal to see some change in gray matter volume or thickness over time as people age. But the changes were more extensive than normal in those who had been infected with COVID-19."
We are all playing Covid roulette. Without clean air, the next infection could permanently disable you | George Monbiot
As rich people plough money into ventilation to protect themselves, those with long Covid are treated as an embarrassment, says Guardian columnist George Monbiot
Does Covid Lead to Dementia? Here's What the Virus May Have Done to Your Brain
Many of Covid’s earliest and most alarming effects involve the brain, including a lost sense of smell, sluggish thinking, headaches, delirium and strokes. More than four years after the pandemic began, researchers are recognizing the profound impacts Covid can have on brain health, as millions of survivors suffer from persistent issues such as brain fog, depression and cognitive slowing, all of which hinder their ability to work and otherwise function. Scientists now worry that these symptoms may be early indicators of a coming surge in dementia and other mental conditions, prolonging the pandemic’s societal, economic and health burden.
COVID-19 may Enduringly Impact Cognitive Performance and Brain Haemodynamics in Undergraduate Students
94 undergraduates post-COVID-19 infection found 40% reported cognitive impairments, with altered brain activity patterns similar to much older adults
More than “Brain Fog”: Cognitive Dysfunction and the Role... : Cardiopulmonary Physical Therapy Journal
This paper dives deep into the complexities of cognitive dysfunction in people with Long COVID—what many call “brain fog” but what is actually a much more debilitating symptom. It’s not just about forgetting where you left your keys; it’s about struggling to work, parent, or even read without triggering post-exertional symptom exacerbation (PESE)—a worsening of symptoms after even minor physical, cognitive, or emotional effort.
Cerebromicrovascular mechanisms contributing to long COVID: implications for neurocognitive health
This review investigates key pathophysiological mechanisms contributing to cerebrovascular dysfunction in long COVID and their impacts on brain health. We discuss how endothelial tropism of SARS-CoV-2 and direct vascular infection trigger endothelial dysfunction, impaired neurovascular coupling, and blood–brain barrier disruption, resulting in compromised cerebral perfusion. Furthermore, the infection appears to induce mitochondrial dysfunction, enhancing oxidative stress and inflammation within cerebral endothelial cells. Autoantibody formation following infection also potentially exacerbates neurovascular injury, contributing to chronic vascular inflammation and ongoing blood–brain barrier compromise. These factors collectively contribute to the emergence of white matter hyperintensities, promote amyloid pathology, and may accelerate neurodegenerative processes, including Alzheimer’s disease.
Increased post-COVID-19 behavioral, emotional, and social problems in Taiwanese children
Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has remarkably impacted children's me…
Neurological and psychiatric risk trajectories after SARS-CoV-2 infection: an analysis of 2-year retrospective cohort studies including 1 284 437 patients
Lancet study shows extreme increases in strokes, seizures, cognitive deficits (including dementia), psychotic disorders and brain swelling in kids and young people 2 years after acute infection.
Neural basis of fatigue in post-COVID syndrome and relationships with cognitive complaints and cognition
The main objective was to evaluate structural and functional connectivity correlates of fatigue in post-COVID syndrome, and to investigate the relatio…
Vaccination prior to SARS-CoV-2 infection does not affect the neurologic manifestations of long COVID
Mukherjee et al. report that vaccination prior to SARS-CoV-2 infection does not affect the neurological manifestations of Long COVID. Minor symptom differe
Frontiers | Diagnostic challenges of long COVID in children: a survey of pediatric health care providers’ preferences and practices
IntroductionGiven the challenges in diagnosing children with long COVID, we sought to explore diagnostic practices and preferences among clinicians.MethodsA ...
Consequences beyond acute SARS-CoV-2 infection in children
Understanding the drivers of pediatric Long Covid and MIS-C is essential for developing therapeutic interventions.
SARS-CoV-2 Infection and New-Onset Type 2 Diabetes Among Pediatric Patients
Cohort study of over 600K patient records found that children and teenagers who have had Covid are 50% more likely to develop diabetes.
Onset of Postural Orthostatic Tachycardia Syndrome (POTS) Following COVID-19 Infection: A Pediatric Case Report
Children and adolescents experience unique long COVID symptoms
A study characterizes childhood long COVID, revealing distinct symptoms in children and adolescents, highlighting the need for tailored diagnostic approaches.
Covid-19 Found in People’s Blood Months After Infection
Researchers provide an important clue to Long Covid, finding viral proteins in the blood of 25% of people more than a year after infection.
A 24-month National Cohort Study examining long-term effects of COVID-19 in children and young people
Communications Medicine - Stephenson, Pinto Pereira et al. investigate the proportion of children and young people with Post Covid-19 condition 24-months post-infection. Only 7.2% meet the...
University of Alberta researchers retract COVID study, citing multiple errors | CBC News
A University of Alberta study on long COVID in children has been retracted.
‘Concern is real’ about long Covid’s impact on Americans and disability claims, report says
The National Academy of Sciences finds that long Covid is affecting adults and children alike, in ways that may not be captured by the Social Security Administration.
Neuroimaging findings in children with COVID-19 infection: a systematic review and meta-analysis
Scientific Reports - Neuroimaging findings in children with COVID-19 infection: a systematic review and meta-analysis
The long-term neurodevelopmental outcomes of toddlers with SARS-CoV-2 infection in the neonatal period: a prospective observational study - Italian Journal of Pediatrics
Background The effect of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) virus in the neonatal period on developing brain is still unknown. This study aims to investigate the long-term neurodevelopmental outcomes of newborns exposed to SARS-CoV-2 & Delta variant. Methods At a tertiary referral center, a prospective observational cohort research was carried out. All babies who were equal to or more than 34 gestational weeks gestation and were admitted to the NICU between January 2021 and January 2022 due to SARS-CoV-2 infection (Delta - or Delta +) were included in the study. Infants who were hospitalized for non-SARS-CoV-2 reasons at similar dates and who had no history of invasive mechanical ventilation were incorporated as a control group using a 2:1 gender and gestational age match. Thirty infants were assigned to the study group and sixty newborns to the control group based on the sample size calculation. These toddlers’ neurodevelopment was evaluated between the ages of 18 and 24 months using the Bayley-II scale. Results We enrolled 90 infants. SARS-CoV-2-positive infants had poorer psychomotor development index (PDI) scores and significantly greater mildly delayed performances (MDPs) at 18–24 months (PDI p = 0.05, MDPs p = 0.03, respectively). Delta variant showed statistically significant lower MDI and PDI scores (MDI p=0.03, PDI p=0.03, respectively). A smaller head circumference of SARS-CoV-2-positive toddlers was detected in the first year (p
Cardiopulmonary Exercise Testing in Children With Long... : The Pediatric Infectious Disease Journal
VID (LC), while the evidence about its role in children with this condition is scarce. Methods: Prospective, case-controlled observational study. Children with LC and a control group of healthy children underwent CPET. CPET findings were compared within the 2 groups, and within the LC groups according to main clusters of persisting symptoms. Results: Sixty-one children with LC and 29 healthy controls were included. Overall, 90.2% of LC patients (55 of 61) had a pathologic test vs 10.3% (3/29) of the healthy control. Children with LC presented a statistically significant higher probability of having abnormal values of peak VO2 (P = 0.001), AT% pred (P
COVID study: 40% of children still infectious after symptom resolution
The median time to symptom resolution was 6 days, and 12% of participants still had symptoms at day 10.